ABSTRACT
Objective To examine the expression of inducible nitric oxide synthase(iNOS) and activation of neuroglia cells in the brain of app/ps1 double transgenic mouse(app/ps1 dtg). Methods The brain sections from 6 app/ps1 dtg and 3 wild type female mice aged at 10 to 12 month were subjected to immunohistochemistry and Congo red histological staining,and observed under microscope. Results The widespread neuritic plaques were observed in the hippocampus and cerebral cortex of app/ps1 dtg mice.These plaques were surrounded by activated microglia cells and astrocytes,and the activated astrocytes expressed iNOS.Conclusion The findings in the present study indicate that app/ps1 dtg mice could mimic the main pathological changes similar to those in Alzheimer disease(AD),suggesting neuroglia activation and expression of iNOS play an important role in app/ps1 dtg mice and AD.